MovDisordV3, Main, Exploration, bibRecord, 004D86

Changes in handwriting resulting from bilateral high‐frequency stimulation of the subthalamic nucleus in Parkinson's disease

Identifieur interne : 004D86 ( Main/Exploration ); précédent : 004D85; suivant : 004D87

Changes in handwriting resulting from bilateral high‐frequency stimulation of the subthalamic nucleus in Parkinson's disease

Auteurs : Hartwig Roman Siebner [Allemagne] ; Andres Ceballos-Baumann [Allemagne] ; Harald Standhardt [Autriche] ; Carola Auer [Allemagne] ; Bastian Conrad [Allemagne] ; Francois Alesch [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-11.

RBID : ISTEX:893F7213F9E38C791683D1290E655C1D64D41232

Descripteurs français

Pascal (Inist)
- Bilatéral, Ecriture, Homme, Noyau sousthalamique, Parkinson maladie, Stimulation instrumentale, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Bilateral, Deep brain stimulation, Dominance, Cerebral (physiology), Electric Stimulation Therapy (instrumentation), Female, Hand writing, Handwriting, Human, Humans, Instrumental stimulation, Male, Middle Aged, Motor Skills (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Prostheses and Implants, STN, Subthalamic Nucleus (physiopathology), Subthalamic nucleus, Treatment, Treatment Outcome, handwriting, “Open‐loop” automatic performance.
MESH :
- instrumentation : Electric Stimulation Therapy.
- physiology : Dominance, Cerebral, Motor Skills.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Female, Handwriting, Humans, Male, Middle Aged, Prostheses and Implants, Treatment Outcome.

Abstract

High‐frequency stimulation of the subthalamic nucleus (STN) is a promising therapeutic approach in patients with severely disabling Parkinson's disease (PD). Whereas STN stimulation improves the cardinal signs of PD, little is known about the effects of STN stimulation on fine manual skills like handwriting. Therefore, the present study investigated the changes in handwriting during bilateral STN stimulation in 12 patients with advanced PD. Dopaminergic medication was discontinued at least 12 hours before the study. The patients were asked to write a standardized sentence repetitively. Five samples of the patient's script were recorded during effective bilateral STN stimulation and 1 hour after both stimulators had been switched off. The movements of the tip of the pencil were recorded using a digitizing tablet. Handwriting movements were segmented into subsequent up‐ and downstrokes, and a stroke‐based kinematic analysis of handwriting was performed. During high‐frequency STN stimulation, handwriting movements became faster and smoother indicating a partial restoration of an “open‐loop” automatic performance. In addition, STN stimulation gave rise to a significant increase in the mean vertical stroke length demonstrating a stimulation‐related reduction in micrographia. The present data underscores the importance of the STN in “open‐loop” performance of highly skilled sequential hand movements.

Url:

https://api.istex.fr/document/893F7213F9E38C791683D1290E655C1D64D41232/fulltext/pdf

DOI: 10.1002/1531-8257(199911)14:6<964::AID-MDS1009>3.0.CO;2-C

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">High‐frequency stimulation of the subthalamic nucleus (STN) is a promising therapeutic approach in patients with severely disabling Parkinson's disease (PD). Whereas STN stimulation improves the cardinal signs of PD, little is known about the effects of STN stimulation on fine manual skills like handwriting. Therefore, the present study investigated the changes in handwriting during bilateral STN stimulation in 12 patients with advanced PD. Dopaminergic medication was discontinued at least 12 hours before the study. The patients were asked to write a standardized sentence repetitively. Five samples of the patient's script were recorded during effective bilateral STN stimulation and 1 hour after both stimulators had been switched off. The movements of the tip of the pencil were recorded using a digitizing tablet. Handwriting movements were segmented into subsequent up‐ and downstrokes, and a stroke‐based kinematic analysis of handwriting was performed. During high‐frequency STN stimulation, handwriting movements became faster and smoother indicating a partial restoration of an “open‐loop” automatic performance. In addition, STN stimulation gave rise to a significant increase in the mean vertical stroke length demonstrating a stimulation‐related reduction in micrographia. The present data underscores the importance of the STN in “open‐loop” performance of highly skilled sequential hand movements.</div>
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Movement Disorders (revue)

Changes in handwriting resulting from bilateral high‐frequency stimulation of the subthalamic nucleus in Parkinson's disease

Changes in handwriting resulting from bilateral high‐frequency stimulation of the subthalamic nucleus in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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